The drone attack on an Isfahan military facility, according to the Iranian defense ministry, was stopped.
Three drones were reportedly involved, according to the ministry, but nobody was hurt.
The ministry added that two drones were caught by "defence traps" and one drone was destroyed by air defense systems, both of which caused minor building damage.
The BBC has not confirmed the extent of the site's damage, and no one has yet to take responsibility.
The "cowardly" incident was an attempt to destabilize the country, according to Iran's foreign minister, Hossein Amir-Abdollahian.
The incident, he continued, would not affect Iran's "determination and intention regarding the peaceful nuclear progress," though.
It happens in the midst of rising tensions related to Iran's nuclear program and its provision of weapons to Russia's war in Ukraine.
The death of a woman who was imprisoned for disobeying Iran's strict dress code incited the nation's recent internal unrest, which has been rife throughout the nation.
The drone strike took place on Saturday night at about 23:30 local time (20:00 GMT), the defense ministry reported in a statement to Iranian state media.
Local authorities referred to the location as a "workshop" but made no comments on the activities there. According to the IRNA news agency, the attack was on "an ammunition manufacturing plant.".
The province of Isfahan is home to a sizable air base as well as a number of nuclear facilities, including Natanz, the hub of Iran's uranium enrichment program.
An oil facility near the northwest city of Tabriz caught fire on Saturday, according to the IRNA news agency. The cause has not been given any further information.
On Iranian military, nuclear, and industrial facilities, there have been a number of explosions, fires, and cyberattacks in recent years.
Israel's defence minister declared that its operations in the region "are not hidden from the eyes of the enemy" after Iran accused Israel in 2021 of sabotaging a crucial nuclear facility close to the city of Natanz.
Assassination of Mohsen Fakhrizadeh, one of Iran's top nuclear scientists, was allegedly carried out by Israel, according to an Iranian claim made in 2020.